Professor, Department of Chemical and Biological Engineering

 

Zhejiang University, Yuquan Campus
38 Zheda Road
Hangzhou, China 310027

 

Other Appointments

Deputy Director, Institute of Biological Engineering

 

Education

Ph.D. – National University of Singapore, 2002
M. S – Tsinghua University, Chemical Engineering, 1998,
B.S. – Tsinghua University, Chemical Engineering, 1995

Working Experience

2007- Professor, Dept. of Chemical and Biological Engineering, Zhejiang University
2005 -2006 Visiting Scientist, California Institute of Technology, United State
2004-2007 Research Fellow, Nanyang Technological University, Singapore
2002 -2003 , Research Fellow, National University of Singapore, Singapore

 

Awards and Honors

Young Scientist Award, the 13th International Biotechnology Symposium

 

Research Interests

1) Enzymatic Engineering;
2) Chiral Drug Separation;
3) Genetic Engineering, Enzyme Directed Evolution;
4) Preparation of Biofuel.

 

Publication List

Selected Publications (First author and/or corresponding author only)
[21] Ren Gangfeng, Yu Hongwei*, Oriented Adsorptive Immobilization of Esterase BioH based on Protein Structure Analysis, Biochemical Engineering Journal, (Accepted)
[20] Wang Bo, Tang Xiaoling, Liu Ji, Ren Gangfeng, Yu Hongwei*, Escherichia coli BioH: a highly enantioselective and organic solvent tolerant esterase for kinetic resolution of sec-alcohols, Tetrahedron Letters, 2010 (51), 6360-6364.
[19] Tang Xiaoling, Liu Ji, Yu Hongwei*, Cloning, screening and characterization of enantioselective ester hydrolases from Escherichia coli K-12, World Journal of Microbiology and Biotechnology. DOI: 10.1007/s11274-010-0437-0
[18] Wang Bo, Liu Ji, Yu Hongwei*, Enzymatic synthesis of (S)-substituted glutaric acid monoesters aided by molecular docking, Tetrahedron Letters, 2010 (51), 309-312.
[17] Liu Ji, Tang Xiaoling, Yu Hongwei*, Prediction of the enantioselectivity of lipases and esterases by molecular docking method with modified force field parameters. Biotechnology and Bioengineering, Volume 105, Issue 4, Date: 1 March 2010, 687-696.
[16] Liu Ji, Yu Hongwei*, Cloning, Screening and Characterization of ester hydrolases with enantioselectivity in typical bacteria. Process Biochemistry, 2010 (45) 475-480.
[15] Wang Bo, Tang Xiaoling, Ren Gangfeng, Liu Ji and Yu Hongwei*, A new high-throughput screening method for determining active and enantioselective hydrolases. Biochemical Engineering Journal, 2009 (46), 345-349.
[14]Yu Hongwei*, Ching Chi Bun, How is effective enantioselectivity of immobilized enzyme in kinetic resolution of racemate affected in a fixed-bed reactor? Industrial & Engineering Chemistry Research, 2008, 47(22), 8808-8814.
[13]Yu Hongwei*, Ching Chi Bun, Adsorption effect on kinetic resolution of racemates catalyzed by immobilized enzymes in a batch reactor, Industrial & Engineering Chemistry Research, 2008, 47(12), 4251-4255.

Before Joining ZJU

[12] Chen Hong, Wang Li-Shan, Liu Li-Hong, Ching Chi Bun, Yu Hongwei*, Yang Yi-Yan*,Thermally responsive reversed micelles for immobilization of enzymes, Advanced Functional Materials, 2008, 18, 95-102.
[11]Yu Hongwei*, and Ching Chi Bun, Cross-linked Enzyme Aggregates (CLEAs) with Controlled Particles: Application to Candida rugosa lipase, Journal of Molecular Catalysis B: Enzymatic, Dec. 2006, 124-127.
[10]Yu Hongwei*, Ching Chi Bun, Effects of salts on activity and stability of Candida rugosa lipase in isooctane, Journal of Molecular Catalysis B: Enzymatic, 2005, Volume 81, Issue 1-3, 38-42.
[9]Yu Hongwei*, Ching Chi Bun, Kinetic resolution of ibuprofen in ionic liquid by Candida rugosa lipase, Chirality, 2005, Volume 17, Issue 1, 16-21.
[8]Wu Yan Xia , Yu Hongwei* , Ching Chi Bun, The Computational Fluid Dynamics (CFD) Simulation of Chromatography with Adsorption Process, Chemical Engineering & Technology, 2004, 27: No9.
[7]Yu Hongwei*, Wu Jinchuan; Ching Chi Bun, Enhancement of activity and enantioselectivity of Candida rugosa lipase immobilized on macro porous resin, Biotechnology Letters, 2004, 26: 629-633.
[6]Yu Hongwei*, Ching Chi Bun, Calculation of chromatographic band profiles using computational fluid dynamics (CFD), Chromatographia, 2003, 58, 793-796.
[5]Yu Hongwei*, Ching Chi Bun, Modeling, Simulation and operation performance of a simulated moving bed for enantioseparation of fluoxetine on new b-Cyclodextrin columns, Adsorption,2003,9 (3):213-223.
[4]Yu Hongwei*, Wu Yan Xia, Ching Chi Bun, Determination of adsorption isotherm of fluoxetine by adjustable fator h-root method (AF-HRM), Chromatographia, 2003,Volume 58.
[3]Yu Hongwei*, Ching Chi Bun, Design and Optimization of a simulated moving bed based on an approximated model using a novel shortcut method, AICHE Journal, 2002, vol. 48, No.10.
[2]Yu Hongwei*, Fu Ping, Ching Chi Bun, Ng Siu Chong, Enantioseparation of fluoxetine on a new b-Cyclodextrin column by HPLC, Separation Science and Technology, 2002, 37(6), 1-15.
[1]Yu Hongwei*, Ching Chi Bun, Kinetic and Equilibrium Study of the Enantioseparation of Fluoxetine on A New b-Cyclodextrin column by HPLC, Chromatographia, 2001, Volume 54, 11/12.

Books
“Modern Pharmaceutical Technology” Chapter Two, 2004. Teaching Materials for Dept. of Chemical Engineering of Tianjin University.

 

Conference List

[1] Liquid chromatographic retention behavior and enantioseparation of fluoxetine on a new beta-cyclodextrin bonded-phase column Yu Hongwei; Ching Chi Bun “Regional Symposium on Chemical Engineering 1999” in Thailand; P-sep. 49-1.
[2] Enantioseparation of fluoxetine on a new beta-cyclodextrin bonded phase column by HPLC Yu Hongwei; Ching Chi Bun “The 2nd PacificBasin Conference on Adsorption Science and Technology” in 2000, in Brisban, Australia
[3] Enatioseparation of fluoxetine by simulated moving bed Yu Hongwei; Ching Chi Bun “The 3nd PacificBasin Conference on Adsorption Science and Technology” in 2003, in Kyejong, Korea.
[4] Kinetic resolution of ibuprofen in ionic liquid by Candida rugosa Yu Hongwei; Ching Chi Bun “Regional Symposium on Chemical Engineering 2003” in Philippine.
[5] Enhanced activity and enantioselectivity of Candida rugosa lipase immobilized on macroporous adsorptive resins for ibuprofen resolution Yu Hongwei; Ching Chi Bun “The 2nd international congress on biocatalysis in 2004”, in Hanmburg, Germany.
[6] Chiral separation by biocatalysts---effect of salts on Candida rugosa lipase in Isooctane. Yu Hongwei; Chen Hong; Ching Chi Bun “Recent Advances in Separation and Purification Techniques for Biological and Pharmaceutical Products Development 2005, Singapore”
 

Patent List

U.S. Patents
Thermally responsive reversed micelles for immobilization of enzymes (Patent Application No. 04227/00/US)