Professor, Department of Chemical and Biological Engineering

 

The 10th Building
Zhejiang University, Yuquan Campus
38 Zheda Road
Hangzhou, China 310027

 

Other Appointments

Director, Laboratory of Second Resource Chemical Engineering
Deputy Director, Centre of Drug Innovation of Zhejiang University

 

Professional Activities

Executive Board Member of Asian Federation of Biotechnology (AFOB)
Fellow, Chemical Industry and Engineering Society of China
Fellow, Biochemistry and Molecular Biology Society of China
Deputy Director, Biochemistry and Molecular Biology Society of Zhejiang Province
Deputy Director, Chemical Industry and Engineering Society of Zhejiang Province
Chair of editorial board, Journal of Chemical Engineering of Chinese Universities
Member of editorial board, Bioprocess and Biosystems Engineering (International)
Member of editorial board, Recent Patents on Chemical Engineering (International)
Member of editorial board, Frontiers of Chemical Science and Engineering (China)
Member of editorial board, CIESC Journal (China)
Member of editorial board, Huaxue Gongcheng (China)
Member of editorial board, Chemical Reaction Engineering and Technology(China)
Member of editorial board, Journal of Food and Biotechnology(China)

 

Education

Ph.D. –Technical University Berlin, Germany, Biotechnology, 1996
M. S –Zhejiang University, Chemical Engineering Department, 1984
B.S. –Zhejiang University, Chemical Engineering Department, 1982

Working Experience

2001-2009, Chair, Department of Chemical and Biological Engineering, Zhejiang University
1996-2000, Deputy Chair, Department of Chemical Engineering, Zhejiang University
1997-now , Professor, Department of Chemical and Biological Engineering, Zhejiang University
1992 - 1996, Assistant and Doctorate, Institute of Biotechnology, Technical University of Berlin, Germany,
1991 - 1997, Associate professor, Department of Chemical Engineering, Zhejiang University
1986 - 1991, Lecturer, Department of Chemical Engineering, Zhejiang University
1984 - 1986, Assistant professor, Department of Chemical Engineering, Zhejiang University

 

Awards and Honors

Qiushi Distinguished Professor of Zhejiang University, 2008
Science and Technology Award of Zhejiang Province, Second prize, 2010
National Education Award of China, First prize, 2005
National Education Award of China, First prize, 2009

 

Research Interests

Bioseparation Engineering
Biopharmaciutic Engineering
Biomaterial

 

Current Projects

1. Bioseparation matrices, methods and integration for antibody purification, Key project of National Natural Science Foundation of China
2. Study on the colon-specific drug delivery system based on the cellulose sulfate as main material, Project of National Natural Science Foundation of China
3. Fundament on the cell factory for biorefinery—Design and construction of “cell factory” model, Project National Basic Research Program of China ( “973”)

Publication List

4 books and more than 150 articles were published in international Journal.
Selected Publications:
(1) Guan YX, Fei ZZ, Luo M, Jin T, Yao SJ，Chromatographic refolding of recombinant human interferon gamma by an immobilized sht GroEL191-345 column, Journal of Chromatography A, 1107, 192–197, 2006
(2) Lin DQ, Miao ZJ，Yao SJ， Expansion and hydrodynamic properties of cellulose-stainless steel powder composite matrix for expanded bed adsorption, Journal of Chromatography A, 1107(1-2), 265-272, 2006
(3) Lu J., Lin DQ, Yao SJ, Preparation of EOPO-IDA-metal as Immobilized Metal Affinity Ligand in Temperature-induced Aqueous Two-phase Extraction, Ind. Eng. Chem. Research, 45(5), 1774 - 1779, 2006
(4) Yao SJ，GuanYX, Lin DQ，Mass Transfer Behaviors of Solutes in NaCS-PDMDAAC Capsules, Ind. Eng. Chem. Research, 45(5), 1811-1816, 2006
(5) Jin T, Guan YX, Yao SJ, Lin DQ, Cho MG，On-column refolding of recombinant human interferon-gamma inclusion bodies by expanded bed adsorption chromatography, Biotechnology and Bioengineering, 93 (4): 755-760, 2006
(6) Zhang J, Guan YX, Ji Z，Yao SJ., Effects on Membrane Properties of NaCS-PDMDAAC Capsules by Adding Inorganic Salts, Journal of Membrane Science, 277, 270-276, 2006
(7) Gao D，Lin DQ, Yao SJ，Measurement and Correlation of Protein Adsorption with Mixed-mode Adsorbents Taking into Account the Influences of Salt Concentration and pH, Journal of Chemical Engineering Data, 51(4), 1205-1211, 2006
(8) Lin DQ, Zhong L.N, Yao SJ，Zeta Potential as a Diagnostic Tool to Evaluate the Biomass Electrostatic Adhesion during Ion-exchange Expanded Bed Application, Biotechnology and Bioengineering, 95(1), 185-191,2006
(9) Gao D，Lin DQ, Yao SJ，Protein adsorption kinetics of mixed-mode adsorbent with benzylamine as functional ligand, Chemical Engineering Science, 61, 7260 – 7268, 2006
(10) Zhao YN, Chen G, Yao SJ，Microbial production of 1,3-propanediol from glycerol by，encapsulated Klebsiella pneumoniae，Biochemical Engineering Journal, 32, 93–99, 2006
(11) Lin DQ, Dong JN, Yao SJ，Target control of cell disruption to minimize the biomass electrostatic adhesion during anion-exchange expanded bed adsorption, Biotechnology Progress, 23 (1): 162-167, 2007
(12) Xia HF，Lin DQ, Yao SJ，Evaluation of new high-density ion exchange adsorbents for expanded bed adsorption chromatography，Journal of Chromatography A, 1145(1-2), 58-66, 2007
(13) Wu Y, Yao SJ，Guan YX，Inactivation of Microorganisms in Carbon Dioxide at Elevated Pressure and Ambient Temperature, Ind. Eng. Chem. Res., 46, 6345-6352, 2007
(14) Gao D，Lin DQ，Yao SJ，Mechanistic analysis on the effects of salt concentration and pH on protein adsorption onto a mixed-mode adsorbent with cation ligand，Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 859(1), 16-23, 2007
(15) Xia HF，Lin DQ, Yao SJ, Preparation and characterization of macroporous cellulose–tungsten carbide composite beads for expanded bed applications，Journal of Chromatography A, 1175, 55–62, 2007
(16) Cai MQ, Guan YX, Yao SJ, Zhu, ZQ，Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) for micronization of levofloxacin hydrochloride，Journal of Supercritical Fluids, 43（3）, 524-534, 2008
(17) Gao D, Yao SJ， Lin DQ, Patch controlled protein adsorption in mixed-mode chromatography with benzylamine as functional ligand, Biochemical Engineering Journal, 38(3), 355-361, 2008
(18) Xia HF, Lin DQ，Yao SJ，Chromatographic performance of macroporous cellulose-tungsten carbide composite beads as anion-exchanger for expanded bed adsorption at high fluid velocity，Journal of Chromatography A，1195(1-2), 60-66, Jun 27,2008
(19) Xia HF, Lin DQ, Wang LP, Chen ZJ, Yao SJ, Preparation and Evaluation of Cellulose Adsorbents for Hydrophobic Charge Induction Chromatography, Ind. Eng. Chem. Res., 47, 9566–9572, 2008,
(20) ZYuan HN, Yao SJ，Shen, LQ; Mao JW, Preparation and Characterization of Inclusion Complexes of β-Cyclodextrin--BITC/ β-Cyclodextrin—PEITC, Ind. Eng. Chem. Res., 48（10）, 5070-5078, 2009
(21) Wang MJ, Xie YL, Zheng QD, Yao SJ, A Novel, Potential Microflora-Activated Carrier for a Colon-Specific Drug Delivery System and Its Characteristics, Ind. Eng. Chem. Res., 48（11）, 5276–5284, May 6, 2009
(22) Ge X, Guan YX, Chen J, Yao Z, Cao K, Yao SJ，Refolding of Lysozyme In Vitro Assisted by Colloidal Thermosensitive Poly(N-isopropylacrylamide) Brushes Grafted onto the Surface of Uniform Polystyrene Cores，Journal of Applied Polymer Science, 114, 1270–1277 ，2009
(23) Xie Y. L，Wang MJ，Yao SJ，Preparation and Characterization of Biocompatible Microcapsules of Sodium Cellulose Sulfate/Chitosan by Means of Layer-by-Layer Self-Assembly，Langmuir, 25(16), 8999–9005, 2009
(24) Zhao J，Lin DQ，Yao SJ, Expansion and hydrodynamic properties of β-cyclodextrin polymer/tungsten carbide composite matrix in an expanded bed，Journal of Chromatography A，1216(45), 7840-7845, 2009
(25) Wang Q, Guan YX, Yao SJ, Zhu ZQ，Microparticle formation of sodium cellulose sulfate using supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer，Chemical Engineering Journal, 159, 220–229, 2010
(26) Zhao J，Lin DQ, Wang YC, Yao SJ，A novel β-cyclodextrin polymer / tungsten carbide composite matrix for expanded bed adsorption: Preparation and characterization of physical properties，Carbohydrate Polymers，80(4), 1085-1090, 2010
(27) Zhu LY, Lin DQ, Yao SJ，Biodegradation of polyelectrolyte complex films composed of chitosan and sodium cellulose sulfate as the controllable release carrier，Carbohydrate Polymers，82, 323–328 , 2010
(28) Shi F, Lin DQ， Phottraithip Wimonrat， Yao SJ， Preparation of cellulose-tungsten carbide composite beads with ionic liquid for expanded bed application, Journal of Applied Polymer Science, 119(6), 3453-3461, 2011
(29) Wang Q, Guan YX, Yao SJ, Zhu ZQ,Controllable preparation and formation mechanism of BSA microparticles using supercritical assisted atomization with an enhanced mixer, Journal of Supercritical Fluids, 56, 97-104, 2011
(30) Tan JY, Ren Y.R, Yao SJ, Preparation of Micro-scaled Multilayer Capsules of Poly- dimethyl-diallyl-ammonium chloride and Sodium Cellulose Sulfate by Layer-by-layer Self-assembly Technique, Carbohydrate Polymers, 84, 351–357, 2011

 

Patent List

30 patents have been authorized.