Qiushi Chair Professor
Department of Chemical and Biological Engineering

 

Zhejiang University, Yuquan Campus
38 Zheda Road
Hangzhou, China 310027
 

Other Appointments

Director, Center for Bionanoengineering
Adjunct Professor, Soft Materials Laboratory (SML) and Department of Chemical & Petroleum Engineering, University of Wyoming, Laramie,
 

Professional Activities

Member of American Institute of Chemical Engineers (AIChE)
Member of American Chemical Society (ACS)
American Association for the Advancement of Science (AAAs)
Session Chair of ACS Fall Nation Meeting 2003, 2006 Polymer Materials Science and Engineering
US NSF Panel Reviewer 2003, 2005, 2006, 2007(3 times),2008; NSF and NSERC (Canada) proposal hoc reviewer
Director, Soft Materials Laboratory
Associate editor for Current Nanoscience (Bentham Science Publisher)
Editorial Board Member, Chinese Journal of Chemical Engineering (English Ed)
National Natural Science Foundation of China Panel Review Member
 

Education

Ph.D. – McMaster University, Chemical Engineering, 2001
D. S – Zhejiang University, Polymer Science and Engineering, 1995,
B. S. – Zhejiang University, Chemistry, 1991

Working Experience

2008-present: Qiushi Chair Professor and NSFC Distinguished Young Scholar, Director, Center for Bionanoengineering, Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou, China 310027
Adjunct Professor, University of Wyoming, Laramie, WY, USA 82071-3295
2007-2008: Tenured Associate Professor and Director of Soft Materials Laboratory, Department of Chemical and Petroleum Engineering/ Program of Molecular Cellular and Life Sciences (MCLS)/Center for Cardiovascular Research and Alternative Medicines, University of Wyoming, Laramie, WY, USA 82071-3295
2002-2007: Assistant Professor, Department of Chemical and Petroleum Engineering and Department of Chemistry, University of Wyoming, Laramie, WY, USA 82071-3295
 

Awards and Honors

National Distinguished Young Investigator, 2008

National Outstanding Dissertation Award, 1999

 

Research Interests

Polymer reaction engineering
Biomaterials,
Bionanoengineering and nanomedicines
Gene and drug delivery

 

Current Projects

1. National Natural Science Foundation of China Distinguished Young Scholar Award, 2008-2012, 2000,000 RMB, PI
2. “973” Program “Nuclear Drug Delivery Overcoming cancer drug delivery”, 2009-2011, 700,000RMB, PI
3. National Natural Science Foundation of China “Nuclear localizing polymer-drug conjugate”, 2009-2011, 340,000 RMB, PI
4. National Natural Science Foundation of China, Special Program “Efficient synthesis of topological macromolecules”, 2011-2015, 2600,000 RMB, PI

Selected Previous Projects
 

1. US-NSF: Template-controlled living polymerization for synthesis of self-assembling polymers, 10/15/2003-3/31/2006, $99,943, PI.
2. US NSF-BES: Rational Design of Anticancer Drug Resistance Nanoparticles, 6/1/2004-5/30/2007, $317,024, PI.
3. American Cancer Society Research Scholar Grant RSG-06-118-01-CDD: Fast Cytoplasmic Drug Delivery for Cancers, 06/18/06-06/17/10, $ 690,000, PI
4. US NSF-DMR 0705298: Rational Design of Degradable Polymers for Gene Delivery, $375,000, 07/15/2007-06/14/2010, PI.
5. US NSF-CBET 0753109: Targeted Nuclear Drug Delivery for Cancer Chemotherapy, $240,138, 6/1/08-5/30/2011, PI
6. US DOD Breast Cancer Concept Award BC062422: Nuclear Drug Delivery for Breast Cancer Chemotherapy, 9/1/2007-8/30/2008, $107,250, PI
7. US DOD Breast Cancer Idea Award BC083821: Breast Cancer-Targeted Nuclear Drug Delivery Overcoming Drug Resistance for Breast Cancer Chemotherapy, 12/1/2008-11/30/2011, $528,939, PI
8. US NSF-CBET 0650608: Self-Assembling Polymers: Synthesis and Characterization, $149,976.00, 06/01/2007-05/31/2009, PI
9. The State of Wyoming: Enhanced Oil Recovery Institute, Polymers for CO2- separation, PI, /01/2004-5/30/2006-5/30/2008, ~$950,000 (direct cost)

Selected Publications (120 in total)
Bionanoengineering and Nanomedicine
 

1. J. Tang, D. Zhu and Y. Shen*, Self-Assembly of Polymers into Soft Nanoparticles and Nanocapsules, invited chapter in Encyclopedia Supramolecular Chemistry: From Molecules to Nanomaterials, John Wiley & Sons, Ltd., in press.
2. Y. Shen*, X. Ma, M. Sui, J. Tang, J. Wang, M. Fan, Degradable pH and thermal responsive photoluminescent dendrimers, Chemistry A European Journal, Online.
3. Z. L. Tyrrell, Y. Shen, M. Radosz, Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers. Progress in Polymer Science 2010, 35(9), 1128-1143.
4. H. Tang, C. J. Murphy, B. Zhang, Y. Shen*, E. A. Van Kirk, W. J. Murdoch, Curcumin polymers for cancer drug delivery, Biomaterials, 2010, 31(27) 7139-7149.
5. Y. Shen*, Z. Zhou, P. Xu, E. Van kirk, W. J. Murdoch, Charge-reversal PAMAM dendrimer for nuclear drug delivery, Nanomedicine (UK), 2010, online early view.
6. H. Tang, C. J. Murphy, B. Zhang, Y. Shen*, E. A. Van Kirk, W. J. Murdoch, Amphiphilic curcumin conjugate forming nanoparticles: in vitro and in vivo anticancer activity, Nanomedicine (UK), 2010,5(6), 855-865.
7. Y. Shen*, E. Jin, B. Zhang, C. Murphy, M. Sui, H. Tang, M. Fan, E. Van Kirk, W. J. Murdoch, Prodrug lipid forming high drug loading multifunctional nanocapsules for cancer intracellular drug delivery, Journal of the American Chemical Society, 2010, 132, 4259-4265.
8. H. Ma, K.R Jones, R. Guo, P. Xu, Y. Shen and J. Ren, Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress, Clinical and Experimental Pharmacology and Physiology 2010, 37, 460–465
9. X. Ma, J. Tang, Y. Shen*, M. Fan, H. Tang and M. Radosz, Facile Synthesis of Dendrimers from Sequential Click Coupling of Asymmetrical Monomers, Journal of American Chemical Society, 2009, 131:14795–14803.
10. Z. Zhou, Y. Shen *, J. Tang, M. Fan, E. A Van Kirk , W. J Murdoch, M. Radosz, Targeted charge-reversal polymer drug conjugate for nuclear drug delivery, Advanced Functional Materials, 2009, 19:3580 - 3589.
11. Y. Shen,* Y. Zhan, H. Tang, P. A. Johnson, E. A. Van Kirk, W. Murdoch, Degradable poly(beta-amino ester) nanoparticles for cancer cytoplasmic drug delivery, Nanomedicine: Nanotechnology, Biology and Medicine, 2009, 5:192-201.
12. J. Xu, J. Tang, L. Zhao, Y. Shen, Advances in the study of tumor pH-responsive polymeric micelles for cancer drug targeting delivery. Yaoxue Xuebao 44(12) (2009) 1328-1335.
13. S. Turdi,; P. Xu, Q. Li, Y. Shen*, P. Kerram, J. Ren*, Amidization of doxorubicin alleviates doxorubicin-induced contractile dysfunction and decreased survival in murine cardiomyocytes, Toxicology Letters 2008, 178:197-201.
14. Y. Shen,* Y. Zhan, J. Tang, P. A. Johnson, M. Radosz, E. A. Van Kirk, W. Murdoch, Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer chemotherapy, AIChE Journal 2008, 54:2979-2989.
15. P. Xu, S. Li, J. Ren*, W. J. Murdoch, M. Radosz, Y. Shen*, Virion-mimicking nanoparticles for gene delivery, Angewandte Chemie International Edition 2008, 47:1260-1264.
16. W J Murdoch, E A Van Kirk, D D Isaak, Y Shen: Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts. Gynecologic Oncology 2008, 110:251-255.
17. Y. Shen,* H. Tang, and M. Radosz, E. A. Van Kirk, W. J. Murdoch, pH-responsive nanoparticles for drug delivery. Invited chapter in Drug Delivery Systems- Methods in Molecular Medicine, Kewal Jain (ed), Humana Press, 2008, 437:183-216.
18. P. Xu, E. A. Van Kirk, Y. Zhan, W. J. Murdoch, M. Radosz, Y. Shen,* Targeted charge-reversal nanoparticles for nuclear drug delivery, Angewandte Chemie International Edition, 2007, 46:4999-5002. Highlighted http://www.nanowerk.com/spotlight/spotid=2113.php
19. N. Wang, A. Dong, M. Radosz, Y Shen,* Degradable thermoresponsive polyethylene glycol analog, Journal of Biomedical Materials Research A, 2007, 84A:148 - 157.
20. N. Wang, A. Dong, E. A. Van Kirk, H. Tang, W. Murdoch, M. Radosz, Y Shen,* Degradable polyethylene glycol analog as versatile drug delivery carriers, Macromolecular Bioscience, 2007, 7: 1187-1198.
21. W. Jin, Y. Zhan, E. A. Van Kirk, L. Liu, P. Xu, W. Murdoch, M. Radosz, Y. Shen,* Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta-aminoester)-graft-PEG for cancer chemotherapy, Drug Delivery 2007, 14:279-286.
22. P. Xu, S. Li, J. Ren, W. J. Murdoch, M. Radosz, Y. Shen*, Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes, Biotechnology and Bioengineering, 2006, 95:893-903.
23. P. Xu, E. A. Van Kirk, W. J. Murdoch, Y. Zhan, D. D. Isaak, M. Radosz, Y. Shen*, Anticancer efficacies of cisplatin-releasing nanoparticles, Biomacromolecules, 2006, 7:829-835.

Selected as one of the four the Most Intriguing work by CAS scientists for 2Q of 2006 from over 200,000 documents per quarter, including articles from nearly 9,500 journals, and patents from 50 active patent-issuing authorities from around the world.
 

1. P. Xu, E. A. Van Kirk, S. Li, J. Ren, W. J. Murdoch, M. Radosz, Y. Shen*, Highly stable core-surface crosslinked nanoparticles as cisplatin carriers, Colloids and Surfaces B: Biointerfaces, 2006, 48:50-57.
2. H. Tang, M. Radosz, Y. Shen,* Synthesis and self-assembly of thymine- and adenine-containing homopolymers and diblock copolymers Journal of Polymer Science Part A: Polymer Chemistry, 2006, 44:5995-6006.
3. H. Tang, M. Radosz, Y. Shen,* Template-atom transfer radical polymerization of diaminopyrimidine derivatized monomer in the presence of uracil-containing polymer Journal of Polymer Science Part A: Polymer Chemistry, 2006, 44:6607-6615.
4. P. Xu, H. Tang, S. Li, J. Ren, E. A. Van Kirk, W. J. Murdoch, M. Radosz, Y. Shen,* Enhanced stability of core-surface crosslinked micelles fabricated from amphiphilic brush copolymers, Biomacromolecules, 2004, 5:1736-1744.

Polymer Reaction Engineering
 

1. L. Zhang, H. Tang, J. Tang, Y. Shen, L. Meng, M. Radosz, N. Arulsamy, Pentadentate Copper Halide Complexes Have Higher Catalytic Activity in Atom Transfer Radical Polymerization of Methyl Acrylate Than Hexadentate Complexes. Macromolecules 2009, 42:4531-4538.
2. W. Winoto, S.P. Tan, Y. Shen, M. Radosz, K. Hong, J.W. Mays, High-Pressure Micellar Solutions of Polystyrene-block-polybutadiene and Polystyrene-block-polyisoprene in Propane Exhibit Cloud-Pressure Reduction and Distinct Micellization End Points. Macromolecules 2009, 42:3823-3826.
3. W. Winoto, S.P. Tan, Y. Shen, M. Radosz, K. Hong, J.W. Mays, High-Pressure Micellar Solutions of Symmetric and Asymmetric Styrene-Diene Diblocks in Compressible Near-Critical Solvents: Micellization Pressures and Cloud Pressures Respond but Micellar Cloud Pressures Insensitive to Copolymer Molecular Weight, Concentration, and Block Ratio Changes. Macromolecules 2009, 42:7155-7163.
4. Z. Tyrrell, W. Winoto, Y. Shen, M. Radosz, Block Copolymer Micelles Formed in Supercritical Fluid Can Become Water-Dispensable Nanoparticles: Poly(ethylene glycol)-block-Poly(ε-caprolactone) in Trifluoromethane. Industrial & Engineering Chemistry Research 2009, 48(4), 1928-1932.
5. Z. Tyrrell, W. Winoto, Y. Shen, M. Radosz, Block Copolymer Micelles Formed in Supercritical Fluid Can Become Water-Dispensable Nanoparticles: Poly(ethylene glycol)-block-Poly(e-caprolactone) in Trifluoromethane. Industrial & Engineering Chemistry Research 2009, 48:1928-1932.
6. J. Tang, Y. Shen, M. Radosz, W. Sun, Isothermal Carbon Dioxide Sorption in Poly(ionic liquid)s. Industrial & Engineering Chemistry Research 2009, 48:9113-9118.
7. H. Tang, M. Radosz, Y. Shen, Atom transfer radical polymerization and copolymerization of vinyl acetate catalyzed by copper halide/terpyridine. AIChE J. 2009, 55:737-746.
8. H. Tang, M. Radosz, Y. Shen, Controlled/"Living" radical polymerization of vinyl acetate. ACS Symp. Ser. 1023(Controlled/Living Radical Polymerization: Progress in ATRP) (2009) 139-157.
9. X. Hu, M. Radosz, Y. Shen, Flue-Gas Carbon Capture on Carbonaceous Sorbents: Toward a Low-Cost Multifunctional Carbon Filter for ?Green’ Energy Producers, Industrial & Engineering Chemistry Research 2008, 47:3783-3794..
10. J. Tang, M. Radosz, and Y. Shen,* Poly(ionic liquid)s as transparent microwave absorbing materials, Macromolecules, 2008, 41:493-496..
11. H. Cong, J. Zhang, M. Radosz, Y. Shen,*Carbon nanotube composite membranes of brominated poly(2,6-diphenyl-1,4-phenylene oxide) for gas separation, Journal of Membrane Science 2007, 294:178-185.
12. H. Cong, X Hu, M. Radosz, Y. Shen,* Brominated Poly(2,6-diphenyl-1,4-phenylene oxide) and Its SiO2 Nanocomposite Membranes for Gas Separation, Industrial & Engineering Chemistry Research 2007, 46:2567-2575.
13. X. Hu, H. Cong, Y. Shen, M. Radosz,* Nanocomposite Membranes for CO2 separations: Silica/Brominated PPO [Poly(phenylene oxide], Industrial & Engineering Chemistry Research 2007, 46:1547-1551.
14. H. Cong, M. Radosz, Y. Shen,* Polymer-inorganic nanocomposite membranes for gas separation, Separation and Purification Technology 2007, 55:281-291.
15. H. Tang, N. Arulsamy, M. Radosz, Y. Shen*, N. V. Tsarevsky, W. A. Braunecker, W. Tang, K. Matyjaszewski*, Highly active catalyst for atom transfer radical polymerization, Journal of American Chemical Society, 2006, 128:16277-16285.

Highlighted in Chemical & Engineering News, 84(44), October 30, 2006, 40-41.
 

1. W. Winoto, H. Adidharma, Y. Shen, Y., M. Radosz*, Micellization Temperature and pressure for polystyrene-block-polyisoprene in subcritical and supercritical propane. Macromolecules, 2006, 39:8140-8144.
2. S. Ding, M. Radosz, Y. Shen*, Magnetic supported catalyst for ATRP. Chapter in Progress in Controlled/Living Polymerization: From Synthesis to Materials, ACS Symposium. Series 2006, 944:71-84.
3. S. Ding, M. Radosz, Y. Shen*, Magnetic nanoparticle supported catalyst for atom transfer radical polymerization, Macromolecules, 2006, 39:6399-6405.

Most-Accessed Articles in Macromolecules: July-September, 2006
 

1. S. Ding, M. Radosz, Y. Shen*, Ionic liquid supported catalyst for atom transfer radical polymerization, Macromolecules 2005, 38:5921-5928.
2. J. Tang, H. Tang, W. Sun, H. Plancher, M. Radosz, Y. Shen*, Poly(ionic liquid): A new material for enhanced and fast absorption of CO2, Chemical Communication, 2005, 3325-3327.

(Highlighted in Chemical & Engineering News’s cover story Membranes For Gas Separation 2005, 83 (40) 49-57).
 

1. J. Tang, H. Tang, W. Sun, M. Radosz, Y. Shen*, Enhanced CO2-absorption of poly(ionic liquid)s, Macromolecules 2005, 38:2037-2039.
2. Y. Shen,* H. D. Tang, and S. Ding, Catalyst separation in atom transfer radical polymerization, Progress in Polymer Science, 2004, 29, 1053-1078.
3. J. Yang, S. Ding, M. Radosz, Y. Shen*, Reversible catalyst supporting via hydrogen bonding-mediated self assembly for atom transfer radical polymerization of MMA, Macromolecules, 2004, 37:1728-1734.
4. Y. Shen, S. Zhu and R. Pelton, Packed column reactor for the continuous atom transfer radical polymerization of methyl methacrylate and its block copolymerization, AIChE Journal, 2002, 48:2609-2619.
5. Y. Shen, S. Zhu and R. Pelton, Atom transfer radical polymerization of methyl methacrylate mediated by copper bromide-tetraethyldiethylenetriamine grafted on soluble and recoverable poly(ethylene-b-ethylene glycol) supports, Macromolecules 2001, 25:8603-8609.
6. Y. Shen, S. Zhu and R. Pelton, Effects of supporting spacer on the supported atom transfer radical polymerization of methyl methacrylate, Macromolecules 2001, 34:5812-5818.
7. Y. Shen, S. Zhu and R. Pelton, Soluble and recoverable support for copper bromide-mediated living radical polymerization, Macromolecules 2001, 34, 3182-3185.
8. Y. Shen, F. Zeng, S. Zhu and R. Pelton Novel cationic macromonomers by living anionic polymerization of 2-(dimethylamino)ethyl methacrylate, Macromolecules 2001, 34:144-150.
9. Y. Shen, S. Zhu and R. Pelton A capping method for nitrogen anion-initiated living anionic polymerization for synthesizing alkyl methacrylate macromonomers, Macromolecules 2001, 34:376-381.
10. Y. Shen, S. Zhu, F. Zeng, and R. Pelton, Atom transfer radical polymerization of methyl methacrylate by silica gel supported copper bromide/mutidentate amine, Macromolecules 2000, 33:5427-5431.
11. Y. Shen, S. Zhu, F, Zeng, and R. Pelton, Versatile initiators for macromonomer synthesis of acrylates, methacrylates and styrene by atom transfer radical polymerization, Macromolecules 2000, 33:5399-5404.
12. F. Zeng, Y. Shen, S. Zhu and R. Pelton, Synthesis and characterization of comb-branched polyelectrolytes. 1. Preparation of cationic macromonomers of 2-(dimethylamino)ethyl methacrylate, Macromolecules 2000, 33:1628-1635.
13. Y. Shen, X. Chen, and R. A. Gross, Aliphatic polycarbonates with controlled quantities of D-xylofuranose in the main chain, Macromolecules 1999, 32:3891-3897.
14. Y. Shen, X. Chen, and R. A. Gross, Polycarbonates from sugars: Ring-opening polymerization of 1,2-O-isopropylidene-D-xylofuranose-3,5- cyclic carbonate (IPXTC), Macromolecules 1999, 32:2799-2802.
15. Y. Shen and M. Wan, Tubular polypyrrole synthesized by in situ doping polymerization in the presence of organic function acids as dopants, Journal of Polymer Science: Part A: Polymer Chemistry 1999, 37:1443-1449.
16. Y. Shen, Z. Shen and Y. F. Zhang and K. Yao, Novel rare earth catalysts for the living polymerization and block copolymerization of ?-caprolactone, Macromolecules 1996, 29: 8289-8295.
17.  Y. Shen, Z. Shen, J. Shen and Y. F. Zhang, Characteristics and mechanism of ?-caprolactone polymerization by rare earth halide systems, Macromolecules 1996, 29:3441-3446.