Professor, Department of Chemical and Biological Engineering

 

Zhejiang University
Yuquan Campus, 38 Zheda Road
Hangzhou 310027
P.R. China

 

Professional Activities

Secretary General, Bioengineering Division, Chemical Industry and Engineering Society of Zhejiang (CIESZJ)
Fellow, Chemical Industry and Engineering Society of China
Fellow, Chinese Society of Biochemistry and Molecular Biology

 

Education

Ph. D. – Zhejiang University, Biochemical Engineering, 1997
B.S. – Zhejiang University, Biochemical Engineering, 1992

Working Experience

2007.12 – present, professor, Department of Chemical and Biological Engineering, Zhejiang University
2002.6 – 2007.12, associate professor, Department of Chemical and Biochemical Engineering, Zhejiang University
1998.3 – 2002.6, lecturer, Department of Chemical Engineering, Zhejiang University
2009.1 – 2009.4, visiting professor, School of Engineering and Science, Jacobs University Bremen, Germany
2005.6 – 2005.8, visiting scholar, Institute of Technical Biochemistry, University Stuttgart, Germany
2004.8 – 2004.10, visiting scholar, Institute of Technical Biochemistry, University Stuttgart, Germany
1999.9 – 2001.11, post-doctorate, Institute of Enzyme Technology, Duesseldorf University, in Research Center Juelich, Germany
 

Awards and Honors

Second Award of Technology Progress, Zhejiang Province, China, 2010
First Award of Technology Progress in High Education, Education Committee of Zhejiang Province of China, 2002
First Award of Technology Progress, Education Ministry of China, 1999
First Award of Technology Progress, Education Committee of Zhejiang Province of China, 1997

 

Research Interests

1. Bioseparation Science and Technology
2. Separation Material and Biomaterials
3. Computer Simulation and Bioprocess Design

Current Projects

1. Bioseparation matrices, methods and integration for antibody purification, National Natural Science Foundation of China, 21036005.
2. Molecular interactions in protein separation with chromatography, National Natural Science Foundation of China. 20976154.
3. Multi-functional ligand design and novel platform technology for effective antibody purification, National Natural Science Foundation of China. 20776129.
4. Program for New Century Excellent Talents in University, NCET-08-0483.
5. National Basic Research and Development Program of China (973 Program), 2007CB707805

Publication List (Selected)

Selected Publications
[1] J. Zhao, D.-Q. Lin, S.-J. Yao. A novel beta-cyclodextrin polymer/tungsten carbide composite matrix for expanded bed adsorption: preparation and characterization of physical properties. Carbohyd. Polym., 80(4): 1085-1090, 2010.
[2] L.-Y. Zhu, D.-Q. Lin, S.-J. Yao. Biodegradation of polyelectrolyte complex films composed of chitosan and sodium cellulose sulfate as the controllable release carrier. Carbohyd. Polym., 82: 323-328, 2010.
[3] J. Zhao, D.-Q. Lin, S.-J. Yao. Expansion and hydrodynamic properties of beta-cyclodextrin polymer/tungsten carbide composite matrix in an expanded bed. J. Chromatogr. A, 1216(45): 7840-7845, 2009.
[4] H.-F. Xia, D.-Q. Lin, Z.-J. Chen, S.-J. Yao. Preparation and Evaluation of Cellulose Adsorbents for Hydrophobic Charge Induction Chromatography. Ind. Eng. Chem. Res., 47 (23): 9566–9572, 2008.
[5] H.-F. Xia, D.-Q. Lin, S.-J. Yao. Chromatographic performance of macroporous cellulose–tungsten carbide composite beads as anion-exchanger for expanded bed adsorption at high fluid velocity. J. Chromatogr. A, 1195(1-2): 60-66, 2008.
[6] D.-Q. Lin, S.-J. Yao. Optimizing dye-ligand density with molecular analysis for affinity chromatography of rabbit muscle L-lactate dehydrogenase. Biotechnol. Prog., 23(4): 904-910, 2007.
[7] D.-Q. Lin, J.-N. Dong, S.-J. Yao. Target control of cell disruption to minimize the biomass electrostatic adhesion during anion-exchange expanded bed adsorption. Biotechnol. Prog., 23: 162-167, 2007.
[8] H.-F. Xia, D.-Q. Lin, S.-J. Yao. Preparation and characterization of macroporous cellulose-tungsten carbide composite beads for expanded bed applications. J. Chromatogr. A, 1175(1): 55-62, 2007.
[9] H.-F. Xia, D.-Q. Lin, S.-J. Yao. Evaluation of new high-density ion exchange adsorbents for expanded bed adsorption chromatography. J. Chromatogr. A, 1145(1-2): 58-66, 2007.
[10] D. Gao, D.-Q. Lin, S.-J. Yao. Mechanistic analysis on the effects of salt concentration and pH on protein adsorption onto a mixed-mode adsorbent with cation ligand. J. Chromatogr. B., 859(1): 16-23, 2007.
[11] D.-Q. Lin, Z.-J. Miao, S.-J. Yao. Expansion and hydrodynamic properties of cellulose-stainless steel powder composite matrix for expanded bed application. J. Chromatogr. A, 1107(1-2): 265-272, 2006.
[12] D.-Q. Lin, L.-N. Zhong, S.-J. Yao. Zeta potential as a diagnostic tool to evaluate the biomass electrostatic adhesion during ion-exchange expanded bed application. Biotechnol. Bioeng., 95(1): 185-191, 2006.
[13] J. Lu, D.-Q. Lin, S.-J. Yao. Preparation and application of novel EOPO-IDA-metal polymer as recyclable metal affinity ligand in aqueous two-phase systems, Ind. Eng. Chem. Res., 45(5): 1774-1779, 2006.
[14] D. Gao, D.-Q. Lin, S.-J. Yao. Protein adsorption kinetics of mixed-mode adsorbent with benzylamine as functional ligand. Chem. Eng. Sci., 61(22): 7260-7268, 2006.
[15] J.-X. Yun, D.-Q. Lin, S.-J. Yao. Predictive modeling of protein adsorption along the bed height by taking into account the axial non-uniform liquid dispersion and particle classification in expanded beds. J. Chromatogr. A, 1095(1-2):16-26, 2005.
[16] D.-Q. Lin, J. Thoemmes, M.-R. Kula, J. J. Hubbuch, Influence of biomass on the hydrodynamic behaviour and stability of expanded beds, Biotechnol. Bioeng., 87(3): 337-346, 2004.
[17] J.-X. Yun, D.-Q. Lin, M.-H. Lu, L.-N. Zhong, S.-J. Yao. Measurement and modeling of axial distribution of adsorbent particles in expanded bed: taking into account the particle density difference. Chem. Eng. Sci., 59(24): 5873-5881, 2004.
[18] J.-X. Yun, S.-J. Yao, D.-Q. Lin, M.-H. Lu, W.-T. Zhao. Modeling axial distributions of adsorbent particle size and local voidage in expanded bed. Chem. Eng. Sci., 59(2): 449-457, 2004.
[19] D.-Q. Lin, M.-R. Kula, L. Alisa, J. Thoemmes. Stability of expanded beds during the application of crude feedstock, Biotechnol. Bioeng., 81(1):21-26, 2003.
[20] D.-Q. Lin, P. J. Brixius, J. J. Hubbuch, J. Thoemmes, M.-R. Kula, Biomass/adsorbent electrostatic interactions in expanded bed adsorption: a zeta potential study, Biotechnol. Bioeng., 83(2):149-157, 2003.

 

Conference List

[1] D.-Q. Lin, H.-Y. Wang, H.-F. Xia, S.-J. Yao. Multiscale approach for downstream development: molecular simulation, separation materials to novel bioprocess. The 16th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2010), TaiBei, Nov. 20-22, 2010.
[2] D.-Q. Lin, H.-Y. Wang, H.-F. Xia, S.-J. Yao. Mixed-Mode Ligands for Bio-Product Recovery and Purification. The 3rd World Congress of Industrial Biotechnology 2010 (ibio-2010), Dalian, July 24-27, 2010.
[3] D.-Q. Lin, F. Shi, Shan-Jing Yao. Preparation of Cellulose-based Chromatographic Matrix with Ionic Liquid as the non-derivatizing solvent. The 6th International Conference on Separation Science and Technology (ICSST’ 2010), Changsha, Oct. 26-28, 2010.
[4] D.-Q. Lin, H.-Y. Wang, S.-J. Yao. Molecular insight into the ligand-IgG interactions for hydrophobic charge induction chromatography. The 6th International Conference on Separation Science and Technology (ICSST’ 2010), Changsha, Oct. 26-28, 2010.
[5] D.-Q. Lin, H.-Y. Wang, S.-J. Yao. The interactions between antibody and MEP ligand for hydrophobic charge induction chromatography: a molecular simulation. The 15th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2009), Xiamen, Dec. 18-20, 2009.
[6] D.-Q. Lin, H.-F. Xia, L.-P. Wang, S.-J. Yao. Adsorption design for antibody separation with hydrophobic charge induction chromatography. 13th International Biotechnology Symposium & Exhibition (IBS-2008), Dalian, October 12-17, 2008. Journal of Biotechnology, Volume 136, Supplement 1, October 2008, Pages S496-S497.
[7] D.-Q. Lin, S.-J. Yao. Multi-scale design strategy for downstream processing: a case study of antibody separation. International Symposium on Bioprocess and Biosystems Engineering (ISBBE) 2009, Shanghai, August 3-6, 2009.
[8] T.-T. Zhuang, D.-Q. Lin, S.-J. Yao. Separation of immunoglobulins from porcine plasma with mixed-mode adsorption. International Symposium on Recent Advances in Biotechnologies, The International Symposium on Advanced Bio, Nano and Pharmaceutical Science and Technology 2009, Beijing, May 3-5, 2009.
[9] S.-J. Yao, D.-Q. Lin. Rational design of adsorbent for expanded bed adsorption. International Symposium on Bioprocess and Biosystems Engineering (ISBBE) 2009, Shanghai, August 3-6, 2009.
[10] Wimonrat Phottraithip, D.-Q. Lin and S.-J. Yao. NMMO dissolution method to prepare spherical cellulose-tungsten carbide composite matrix for expanded bed application. The 5th Sino-US Joint Conference of Chemical Engineering, Beijing, Oct. 13-16, 2009
[11] D.-Q. Lin, S.-J. Yao. Rational design of adsorbents for expanded bed applications: mechanism, properties to performance. International Symposium on Recent Advances in Biotechnologies, Hangzhou, April 7-9, 2008.
[12] S.-J. Yao, D.-Q. Lin. Waste into products: efficient separation from low concentration feedstock. Third China-USA Workshop on Chemical Engineering Faculty Research Collaboration, Feb. 24-27, 2008.
[13] H.-F. Xia, D.-Q. Lin, S.-J. Yao. Adsorbent preparation and adsorption behaviors of hydrophobic charge induction chromatography for antibody separation. International Symposium on Recent Advances in Biotechnologies, Hangzhou, April 7-9, 2008.
[14] D.-Q. Lin, S.-J. Yao. Rational design of expanded bed adsorbents towards perfection. The 5th International Conference on Separation Science and Technology, Beijing, Oct. 14-16, 2007

[15] H.-F. Xia, D.-Q. Lin, S.-J. Yao. Macroporous Cellulose-Tungsten Carbide Composite Beads for Expanded Bed Adsorption Application. The 5th International Conference on Separation Science and Technology, Beijing, Oct. 14-16, 2007.
[16] D. Gao, D.-Q. Lin, S.-J. Yao. Protein adsorption behavior of mixed-mode adsorbent with benzylamine as functional ligand. The 5th International Conference on Separation Science and Technology, Beijing, Oct. 14-16, 2007.
[17] J.-N. Dong, D.-Q. Lin, S.-J. Yao. Influence of homogenization techniques on the biomass-adsorbent interaction during ion-exchange expanded bed adsorption: zeta potential study. China/USA/Japan Joint Chemical Engineering Conference. pp173, Beijing, Oct. 11-13, 2005.
[18] D.-Q. Lin, S.-J. Yao, M.-H. Lu, L.-H Mei, Z.-Q. Zhu. Process design in expanded bed adsorption – integration target adsorption and biomass influence. Proceedings of 4th International Conference on Separation Science and Technology – Frontiers on Separation Science and Technology, Z.-F. Tong and S.-H. Kim (eds.), pp395-398, Nanning, Feb. 19-24, 2004.
[19] Y.-L. Lei, D.-Q. Lin, S.-J. Yao, Z.-Q. Zhu. Expanded bed adsorption for recovery of ?-chloropropionic acid dehalogenase using TiO2-densified cellulose adsorbent. Proceedings of 4th International Conference on Separation Science and Technology – Frontiers on Separation Science and Technology, Z.-F. Tong and S.-H. Kim (eds.), pp703-707, Nanning, Feb. 19-24, 2004.
[20] J.-X. Yun, D.-Q. Lin, S.-J. Yao. Nonuniform hydrodynamics and axial dispersion behaviors in expanded beds. Proceedings of 4th International Conference on Separation Science and Technology – Frontiers on Separation Science and Technology, Z.-F. Tong and S.-H. Kim (eds.), pp964-968, Nanning, Feb. 19-24, 2004.

 

Patent List

[1] S.-J. Yao, Z.-Q. Zhu, Y.-L. Lei, D.-Q. Lin, Y.-X.Guan. Homogenous cellulose/titanium dioxide composite beads and the preparation method, Chinese Patent No: ZL02111928.7, applied date: 2002.5.30, authorized date: 2004.9.1
[2] D.-Q. Lin, S.-J. Yao, Z.-J. Miao, Y.-L. Lei, Z.-Q. Zhu. Core-schell type cellulose/stainless steel powder composite beads, Chinese Patent No: ZL03142163.6, applied date: 2003.8.8, authorized date: 2006.3.8
[3] D.-Q. Lin, S.-J. Yao, J. Lu, y.-X. Guan. Affinity ligand for temperature-induced aqueous two-phase partition and the preparation method, Chinese Patent No: ZL200410017753.X, applied date: 2004.4.16, authorized date: 2006.3.15
[4] S.-J. Yao, D.-Q. Lin, J.-X. Yun, Y.-X.Guan. Preparation of active collagen polypeptides from animal tissue, Chinese Patent No: ZL 200410052758.6, applied date: 2004.7.8, authorized date: 2006.5.31
[5] S.-J. Yao, J. Zhang, Y.-X. Guan, D.-Q. Lin. Preparation of macro-porous NaCS-PDADMAAC bio-microcapsule, Chinese Patent No: ZL 200410053010. 8, applied date: 2004.7.16, authorized date: 2006.10.4
[6] S.-J. Yao, Y. Wu, Y.-X. Guan, D.-Q. Lin. Inactivation of microorganisms in Carbon dioxide at elevated pressure and ambient temperature, Chinese Patent No: ZL 200510061997.2, authorized date: 2007.7.11
[7] D.-Q. Lin, H.-F. Xia, S.-J. Yao. Method of enlarging the pores in spherical cellulose beads, Chinese Patent No: 200710067087.4, applied date: 2007.2.9, authorized date: 2009.2.18
[8] D.-Q. Lin, S.-J. Yao, Y.-F. He, H.-F. Xia. Method to separate of egg yolk immunoglobulin, Chinese Patent No: 200710070236.2, applied date: 2007.7.27, authorized date: 2010.5.26
[9] S.-J. Yao, D.-Q. Lin, L. Fang. Method to prepare the starch sulphate, Chinese Patent No：200810061922.8, applied date: 2008.5.27, authorized date: 2010.6.2.
[10] D.-Q. Lin, Z.-Y. Wang, S.-J. Yao, H.-F. Xia, Y.-X. Du. Direct solution Method to prepare cellulose composite beads for expanded bed adsorption, Chinese Patent No：200810062624.0, applied date: 2008.6.27, authorized date: 2010.7.14.
[11] S.-J. Yao, J. Zhao, D.-Q. Lin. Beta-cyclodextrin polymer / tungsten carbide composite microbeads and the preparation method, Chinese Patent No：200810121875.1., applied date: 2008.10.21, authorized date: 2010.7.14.
[12] S.-J. Yao, M.-J. Wang, D.-Q. Lin, Y.-X. Guan. Biodegradable material for microorganisms in the colon and the preparation method, Chinese Patent No: 200710070812.3, applied date: 2007.8.17, authorized date: 2010.8.18.
[13] H.-F. Xia, D.-Q. Lin, S.-J. Yao, L.-P. Wang. Adsorbent with hydrophobic charge induction and thiophilic ligand for expanded bed adsorption and preparation method, Chinese Patent No：200810061814.0, applied date: 2008.5.14, authorized date: 2010.8.18
[14] H.-F. Xia, D.-Q. Lin, S.-J. Yao, L.-P. Wang. Adsorbent with mixed mode ligand for expanded bed adsorption and preparation method, Chinese Patent No：200810061816.X, applied date: 2008.5.14, authorized date: 2010.8.18
[15] S.-J. Yao, D.-Q. Lin, L. Fang. Method to prepare the cellulose sulphate with high substitution, Chinese Patent No：200810061583.3, applied date: 2008.5.7, authorized date: 2010.11.3.
[16] H.-F. Xia, D.-Q. Lin, S.-J. Yao, L.-P. Wang. Adsorbent with 4-mercapto-ethyl-pyridine as the ligand for antibody separation by expanded bed adsorption and preparation method, Chinese Patent No：200810061817.4, applied date: 2008.5.14.
[17] S.-J. Yao, M.-J. Wang, D.-Q. Lin, Y.-X. Guan. Plant capsule with cellulose sulphate as main material and the preparation method, Chinese Patent No: 200810061238.X, applied date: 2008.3.18
[18] D.-Q. Lin, T.-T. Zhuang, S.-J. Yao. One method to separate fibrinogen and immunoglobulin from animal blood, Chinese Patent No：200810121877.0, applied date: 2008.10.21.
[19] D.-Q. Lin, F. Shi, S.-J. Yao, Y.-X. Du. One method to prepare cellulose beads with ionic liquid as the solvent, Chinese Patent No：200910100982.0, applied date: 2009.8.6.
[20] S.-J. Yao, J.-Y. Tan, Q.-L. Ma, D.-Q. Lin. One method to prepare the hollow capsules in micro-scale. Chinese Patent No：201010131147.6, applied date: 2010.3.23.
[21] D.-Q. Lin, H.-F. Tong, S.-J. Yao. One method to separate the immunoglobulin IgY(ΔFc) from goose plasma. Chinese Patent No：201010228683.8, applied date: 2010.7.16.
[22] D.-Q. Lin, H.-F. Tong, S.-J. Yao. One method to separate the immunoglobulin IgY from chickem plasma. Chinese Patent No：201010295422.8, applied date: 2010.9.27.