Professor, Department of Chemical and Biological Engineering

 

Zhejiang University, Yuquan Campus
38 Zheda Road
Hangzhou, China 310027

 

Education

Ph.D. – Zhejiang University, Biochemical Engineering, 1995
B.S. – Tsinghua University, Chemical Engineering, 1989

Working Experience

2005-, Professor, Department of Chemical and Biological Engineering, Zhejiang University
1998-2004, Associate professor, Department of Chemical and Biological Engineering, Zhejiang University
1995-1997, Lecturer, Department of Chemical and Biological Engineering, Zhejiang University
1999-2000, Visiting scholar, Centre for Protein Engineering, University of Cambridge

 

Awards and Honors

1. Preparation of expanded bed adsorption resin and its application in bioseparation process, Science and Technology Award of Zhejiang Province, Second prize, 2010
2. Fundamentals and application on aqueous two-phase partitioning technology, Science and Technology Award of Ministry of Education, First Prize, 1999

 

Research Interests

Supercritical fluid technology based micronization
Protein folding in vivo and in vitro
Biocatalysis and biotransformation on steroids

 

Current Projects

1. Preparation of control-released drugs using supercritical solution impregnation process, supported by National Natural Science Foundation of China, 2011.01-2013.12
2. Refolding of recombinant proteins expressed in inclusion bodies assisted by grafted temperature sensitive polymers in vitro, supported by National Natural Science Foundation of China, 2009.01-2011.12
3. Micronization of aerosol drugs using supercritical assisted atomization improved by hydrodynamic cavitation, supported by National Natural Science Foundation of China, 2007.01-2009.12
4. 4. In vitro refolding of recombinant proteins assisted by foldase, supported by National Natural Science Foundation of China, 2005.01-2007.12
    

Publication List

Miao Shifeng, Yu Jinpeng, Du Zhe, Guan Yixin, Yao Shanjing, Zhu Ziqiang, Supercritical fluid extraction and micronization of ginkgo flavonoids from ginkgo biloba leaves, Industrial & Engineering Chemistry Research, 2010, 49, 5461-5466

1. Tong Shengqiang, Yan Jizhong, Guan Yixin, Fu Yaner, Yoichiro Ito, Separation of α-cyclohexylmandelic acid enantiomers using biphasic chiral recognition high-speed counter-current chromatography, Journal of Chromatography A, 2010, 1217, 3044-3052
2. Wang Qi, Guan Yixin, Yao Shanjing, Zhu Ziqiang, Microparticle formation of sodium cellulose sulfate using supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer, Chemical Engineering Journal, 2010, 159, 220-229

1. Ge Xiang, Guan Yixin, Chen Jie, Yao Zhen, Cao Kun, Yao Shanjing, Refolding of lysozyme in vitro assisted by colloidal thermo-sensitive poly(N- isopropylacrylamide) brushes grafted onto the surface of uniform polystyrene cores, Journal of Applied Polymer Science, 2009, 114, 1270-1277
2. Li Jiuhong, Guan Yixin, Wang Haiqing, Yao Shanjing, Dehydrogenation of 11α-hydroxy-16α,17-epoxyprogesterone by encapsulated Arthrobacter simplex cells in an organic-aqueous two-liquid-phase system, Journal of Chemical Technology and Biotechnology, 2009, 84(2), 208-214
3. Xu Liren, Yan Xiao, Luo Man, Guan Yixin, Yao Shanjing, Preparation, characterization and refolding in vitro of a recombinant human cyclophilin A mutant: effect of a single pro/ser substitution on cyclophilin A structure and properties, Biotechnology Progress, 2008, 24, 302-310
4. Cai Meiqiang, Guan Yixin, Yao Shanjing, Zhu Ziqiang, Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) for micronization of levofloxacin hydrochloride, The Journal of Supercritical Fluids, 2008, 43, 524-534
5. Zhang Jun, Guan Yixin, Ji Zheng, Yao Shanjing, Effects on membrane properties of NaCS-PDMDAAC capsules by adding inorganic salts, Journal of Membrane Science, 2006, 277(1-2), 270-276
6. Guan Yixin, Fei Zhengzheng, Luo Man, Jin Ting, Yao Shanjing, Chromatographic refolding of recombinant human interferon gamma by an immobilized sht GroEL191-345 column, Journal of Chromatography A, 2006, 1107(1-2), 192-197
7. Jin Ting, Guan Yixin, Yao Shanjing, Lin Dongqiang, Cho Mangi, On-column refolding of recombinant human interferon-γ inclusion bodies by expanded bed adsorption chromatography, Biotechnology and Bioengineering, 2006, 93(4), 755-760